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产(R)-3-hydroxybutyrate (3HB) 大肠杆菌Nissle1917

产品编号 产品名称
产(R)-3-hydroxybutyrate (3HB) 大肠杆菌Nissle1917

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The genome-engineered EcN produced the highest 3HB level of 0.6 g/L under microaerobic conditions. The live therapeutic was
found to colonize the mouse gastrointestinal tract over 14 days, elevating gut 3HB and short-chain-length fatty acid (SCFA) levels
8.7- and 3.1-fold compared to those of wild-type EcN, respectively. The sustainable presence of 3HB in mouse guts promoted the

growth of probiotic bacteria, especially Akkermansia spp., to over 31% from the initial 2% of all the microbiome. 

产羟基丁酸的Nissle1917工程菌可以

参考文献:


Construction of a sustainable 3-hydroxybutyrate-producing probiotic Escherichia coli for treatment of colitis
Cellular & Molecular Immunology (2021) 18:2344–2357; https://doi.org/10.1038/s41423-021-00760-2



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